HDAC-IN-71_product_DataBase

Bioactivity	HDAC-IN-71 (Compound 17q) is a potent HDAC inhibitor with IC50 values of 12.6, 14.1, 20, 3, and 72 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC10, respectively. HDAC-IN-71 induces apoptosis and can be used in cancer research[1].
Invitro	HDAC-IN-71 (0-1.6 μM; 24 h) 以剂量依赖性方式抑制菌落的形成，并且在 3.2 μM 浓度完全抑制 DU145 细胞的菌落形成[1]。HDAC-IN-71 (0-1.6 μM; 72 h) 将细胞阻滞在 G2/M 期，并以浓度依赖性方式诱导 DU145 细胞系凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HDAC-IN-71 相关抗体: Cell Migration Assay [1] Cell Line:
In Vivo	HDAC-IN-71 (100, 200 mg/kg; p.o.; daily; 40 days) 在100 mg/kg 和 200 mg/kg 浓度下肿瘤生长抑制（TGI）值分别为 50.92% 和 68.00%[1]。药代动力学分析[1] Parameters
CAS	2995354-52-2
Formula	C19H24N2O5
Molar Mass	360.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jiang Q, et al. Discovery of novel itaconimide-based derivatives as potent HDAC inhibitors for the efficient treatment of prostate cancer. Eur J Med Chem. 2024 Apr 5;269:116315.

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