Orforglipron hemicalcium hydrate_product_DataBase

Bioactivity	Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) is the calcium salt hydrate form of Orforglipron (HY-112185). Orforglipron is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorating the type 2 diabete[1].
In Vivo	Orforglipron hemicalcium hydrate (血浆浓度 0.94-4.8 nM，静脉注射 30 分钟；或 0.05-0.1 mg/mL，灌胃，5 天) 在食蟹猴动物模型中剂量依赖性地抑制食蟹猴的食物摄入，促进胰岛素分泌并降低血糖[1]。Orforglipron hemicalcium hydrate (0.05-1.35 mg/kg，灌胃) 在给药后 2 小时后达到 Cmax，血浆药物暴露增加与剂量增加大致成正比，表明 Orforglipron hemicalcium hydrate 在胃肠道内呈剂量依赖性的被吸收[1]。Orforglipron hemicalcium hydrate 在食蟹猴体内的药代动力学分析 [1]route
CAS	3008544-96-2
Formula	C48H48F2N10O5.1/2Ca.H2O
Molar Mass	921.02
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Pyrazolopyridine derivative having glp-1 receptor agonist effect. WO2018056453A1

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