| Bioactivity | HDAC-IN-70 (compound 4c) is HDAC6 inhibitor with the IC50 values of 64.13 nM, 166 nM, 618 nM and 253 nM for HDAC6, HDAC1, HDAC2 and HDAC4, respectively. HDAC-IN-70 induces cell cycle arrest, apoptosis and necrotic. HDAC-IN-70 can be used for study of leukemia[1]. |
| Invitro | HDAC-IN-70 (compound 4c) (0-120 μM) 对 CCRF-CEM 和 MOLT-4 细胞具有细胞毒性，其 IC50 值分别为 1.82 和 6.73 μM[1]。HDAC-IN-70 (1.82 μM, 24 h) 在 CCRF-CEM 细胞中使周期阻滞在 G2-M 期[1]。HDAC-IN-70 (1.82 μM, 24 h) 增加 CCRF-CEM 细胞总凋亡和坏死百分比[1]。HDAC-IN-70 增加 CCRF-CEM 白血病细胞乙酰化组蛋白 H3、H4 水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HDAC-IN-70 相关抗体: Cell Cycle Analysis[1] Cell Line: |
| Formula | C18H14N4O3 |
| Molar Mass | 334.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Abdulwahab HG, et al. Discovery of novel benzimidazole derivatives as potent HDACs inhibitors against leukemia with (Thio)Hydantoin as zinc-binding moiety: Design, synthesis, enzyme inhibition, and cellular mechanistic study. Bioorg Chem. Published online March 13, 2024. |