| Bioactivity | Glycogen phosphorylase-IN-1 (Compound 42) is an inhibitor for human liver glycogen phosphorylase (hlGPa) and hepatocyte glycogen-derived glucose production with IC50s of 53 and 380 nM, respectively. Glycogen phosphorylase-IN-1 reveals efficacy towards type 2 diabetes[1]. |
| In Vivo | Glycogen phosphorylase-IN-1 (5 mg/kg，静脉注射，单剂量) 抑制肝细胞中的糖原分解，改善胰高血糖素刺激的 Wistar 大鼠血糖升高[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 648926-15-2 |
| Formula | C17H15ClF2N4O4 |
| Molar Mass | 412.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Klabunde T, et al., Acyl ureas as human liver glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. J Med Chem. 2005 Oct 6;48(20):6178-93. |
Glycogen phosphorylase-IN-1
CAS: 648926-15-2 F: C17H15ClF2N4O4 W: 412.78
Glycogen phosphorylase-IN-1 (Compound 42) is an inhibitor for human liver glycogen phosphorylase (hlGPa) and hepatocyte
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