| Bioactivity | Arbaprostil is an orally active PGE1 (HY-B0131) analog. Arbaprostil protects the gastrointestinal mucosa from stomach acid and other irritants, promotes healing rate of gastric ucler through the antisecretory effect[1][2]. |
| In Vivo | Arbaprostil (1-100 μg/kg，静脉注射，单剂量) 在 Wistar 大鼠中以剂量依赖的方式促进近端十二指肠中碳酸氢盐的分泌，加快十二指肠损伤愈合率并预防十二指肠粘膜损伤[1]。Arbaprostil pH 依赖性的抑制 Donryu 大鼠的胃分泌 (1-100 μg/kg，口服，单剂量)，促进胃溃疡愈合 (3-10 μg/kg，口服，一天两次共 4 周)[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 55028-70-1 |
| Formula | C21H34O5 |
| Molar Mass | 366.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li JY, Nagata T, Yoshida M, Yagi N, Katoh K, Haramoto T, Itoh K, Iwasaki A, Matsuo Y. Effect of 15(R)-15-methyl PGE2 (arbaprostil) on duodenal bicarbonate secretion in rat. Gastroenterol Jpn. 1989 Feb;24(1):8-11. [2]. Okabe S, et al., Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats. Jpn J Pharmacol. 1986 Feb;40(2):329-37. |