| Bioactivity | GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7[1]. | ||||||||||||
| In Vivo | GX-201 has a relatively long half-life in mice[1].GX-201 produces analgesia at a free plasma concentration about 3 times the IC50 for high-affinity channel block[1].GX-201 inhibits nociceptive responses induced by formalin and inflammatory pain caused by complete Freund’s adjuvant (CFA)[1]. Animal Model: | ||||||||||||
| Name | GX-201 | ||||||||||||
| CAS | 1788071-27-1 | ||||||||||||
| Formula | C25H27ClF4N2O4S | ||||||||||||
| Molar Mass | 563.00 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Girish Bankar, et al. Selective Na V 1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain. Cell Rep. 2018 Sep 18;24(12):3133-3145. |