| Bioactivity | GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1]. |
| Target | GPX4 |
| Invitro | GPX4-IN-4 (Compound 24; 0-1000 nM; 0-24 h) inhibits HT1080 cell viability in a concentration- and time- dependent manner[1].GPX4-IN-4 (0-10 μM; 72 h) inhibits NCI-H1703 cell viability with EC50s of 0.117 μM and 4.74 μM without and with Fer-1 (HY-100579), respectively[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | GPX4-IN-4 (Compound 24; 100 and 200 mg/kg; i.p.; once) 在小鼠中作用于肾脏的 GPX4 并引发 PD 标志物的表达[1]。尽管在肿瘤组织块中观察到部分目标结合，但 GPX4-IN-4 (50 mg/kg; i.p.; daily for 20 days) 对小鼠 WSU-DLCL2 肿瘤生长没有影响[1]。 Animal Model: |
| Name | GPX4-IN-4 |
| Formula | C22H21ClN2O5S |
| Molar Mass | 460.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Randolph JT, et al. Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo. J Med Chem. 2023 Mar 23;66(6):3852-3865. |