Ep300/CREBBP-IN-8

CAS: 2259641-24-0 F: C25H27F2N5O3 W: 483.51

Ep300/CREBBP-IN-8 (Example 37) is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.014 and 0.018 μ

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Ep300/CREBBP-IN-8 (Example 37) is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.014 and 0.018 μM, respectively. Ep300/CREBBP-IN-8 can be used for the research of cancer[1].
Invitro	Ep300/CREBBP-IN-8 (Example 37) 抑制细胞内 H3K27Ac 活性，其 IC50 为 0.016 μM[1]。Ep300/CREBBP-IN-8 (38 nM-10 mM; 3 days) 抑制 LK2 和 TE-8 细胞生长，GI50 分别为 85.917 μM 和 112.922 μM [1]。 Cell Viability Assay[1] Cell Line:
In Vivo	Ep300/CREBBP-IN-8 (Example 37; 6.25 mg/kg/day; oral; twice daily for 11 days) 抑制小鼠肿瘤增殖[1]。 Animal Model:
Name	Ep300/CREBBP-IN-8
CAS	2259641-24-0
Formula	C25H27F2N5O3
Molar Mass	483.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.

Ep300/CREBBP-IN-4