GPR88 agonist 2_product_DataBase

Bioactivity	GPR88 agonist 2 (compound 53) is a potent and brain-penetrantGPR88 agonist with an EC50 value of 14 µM in GPR88 cAMP functional assay[1].
Invitro	GPR88 agonist 2 在 WT 小鼠纹状体膜中显著增强了 [35S]GTPγS 结合活性(EC50: 8.9 μM)，但 GPR88 agonist 2 在 GPR88 KO 小鼠纹状体膜中无活性[1]。 0 --> GPR88 agonist 2 相关抗体:
In Vivo	GPR88 agonist 2 (20mg/ml, 腹腔注射) 具有良好的血浆暴露 (Cmax:1670 ng/mL) 和可接受的代谢稳定性 (T1/2:4.66h, CL:21mL/mg/kg)[1]。GPR88 agonist 2 (20mg/ml, 腹腔注射) 具有足够的脑穿透性 (Cmax:576 ng/mL)[1]。br/>小鼠药代动力学分析[1]20 mg/kg, ip
Name	GPR88 agonist 2
CAS	2821859-71-4
Formula	C26H33N5O3
Molar Mass	463.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Rahman MT, et al. Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies. J Med Chem. 2021 Aug 26;64(16):12397-12413.

PeptideDB