| Bioactivity | G13KS is a deubiquitinase UCHL1 ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells[1]. |
| Invitro | GK13S (0-1 μM，1 小时) 抑制重组 UCHL1，IC50 为 50 nM[1]。GK13S (1-10 μM, 24 h) 抑制 HEK293 细胞中的胞内 UCHL1[1]。GK13S (5 μM, 72 h) 不影响 HEK293 细胞生长[1]。GK13S (5 μM，48 小时) 降低 U-87 MG 细胞中的泛素水平[1]。 Western Blot Analysis[1] Cell Line: |
| Name | GK13S |
| Formula | C21H22N6O2 |
| Molar Mass | 390.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Grethe C, et al. Structural basis for specific inhibition of the deubiquitinase UCHL1. Nat Commun. 2022 Oct 10;13(1):5950. |