| Bioactivity | FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against HSV-1 and HIV-1[1][2][3][4]. |
| Invitro | FK-3000 (0-5 μg/mL; 48 h) 抑制细胞增殖，抑制 MDA-MB-231，MCF-7，PC-3，A-431，HT-29 和 CT-26细胞的 IC50 值分别为 0.52，0.77，0.22，2.70，0.40 和 1.90 μg/mL[1]。FK-3000 (0.5-5.0 μg/mL; 24-48 h) 以剂量和时间依赖性方式诱导 MDA-MB-231 细胞凋亡[1]。FK-3000 (0.5-5.0 μg/mL; 24-48 h) 以剂量和时间依赖性方式诱导 MDA-MB-231 和 MCF-7 细胞的 G2/M 期阻滞[2]。FK-3000 (0.5-5.0 μg/mL; 60-120 min or 24-48 h) 降低 MDA-MB-231 细胞中的 NF-κB 磷酸化水平和 COX-2 表达[1]。FK-3000 (5.0 μg/mL; 120 min) 有效阻断 MDA-MB-231 细胞中 NF-κB 从细胞质向细胞核的易位[1]。 |
| Name | FK-3000 |
| CAS | 1054312-81-0 |
| Formula | C22H27NO7 |
| Molar Mass | 417.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |