| Bioactivity | CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects[1][2]. |
| Invitro | CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity[1].CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2].CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells[2].CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells[1].CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2]. Cell Proliferation Assay[1] Cell Line: |
| Name | CLEFMA |
| CAS | 1246964-32-8 |
| Formula | C23H17Cl2NO4 |
| Molar Mass | 442.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |