| Bioactivity | Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is the TFA salt form of Elamipretide (HY-P0125). Elamipretide TFA is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury[1][2]. | ||||||
| Target | Cardiolipin peroxidase | ||||||
| In Vivo | Elamipretide TFA (5 mg/kg, i.p., once daily for 3 days) 具有神经保护作用，保护海马体免受线粒体功能障碍的影响，并减轻Lipopolysaccharide (HY-D1056) 诱导的 C57BL/6 小鼠认知障碍模型中的氧化应激和炎症反应[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||
| CAS | 1606994-55-1 | ||||||
| Sequence | {d-Arg}-{Dmt}-Lys-Phe-NH2 | ||||||
| Shortening | {d-Arg}-{Dmt}-KF-NH2 | ||||||
| Formula | C34H50F3N9O7 | ||||||
| Molar Mass | 753.81 | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Zhao W, et al., Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. J Neuroinflammation. 2019 Nov 20;16(1):230. [2]. Sabbah HN,et al., Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure. Circ Heart Fail. 2016 Feb;9(2):e002206. |
Elamipretide TFA
CAS: 1606994-55-1 F: C34H50F3N9O7 W: 753.81
Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is the TFA salt form of Elamipretide (HY-P0125). Elamipretide TFA i
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