| Bioactivity | Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species[1]. | ||||||||||||
| Invitro | Iberverin (0-200 μM，48 小时) 抑制 HCC 细胞的活力和增殖，Huh7、Huh7.5.1 和 SNU739 的 IC50 小于 25 μM[1]。Iberverin (10 μM，24-72 小时) 抑制 Huh7、Huh7.5.1 和 SNU739 细胞的迁移和侵袭[1]。Iberverin (40 μM，12 小时) 可诱导 Huh7、Huh7.5.1 和 SNU739 细胞中线粒体相关细胞凋亡、DNA 损伤并导致 G2/M 细胞周期停滞[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Iberverin 相关抗体: Western Blot Analysis[1] Cell Line: | ||||||||||||
| In Vivo | Iberverin (20 mg/kg，腹腔注射，每 3 天一次，共五个周期) 抑制小鼠 HCC 异种移植肿瘤的生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||||||||
| CAS | 505-79-3 | ||||||||||||
| Formula | C5H9NS2 | ||||||||||||
| Molar Mass | 147.26 | ||||||||||||
| Appearance | 液体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. 1. Zhang Y, et al. Iberverin exhibits antineoplastic activities against human hepatocellular carcinoma via DNA damage-mediated cell cycle arrest and mitochondrial-related apoptosis. Front Pharmacol. 2023 Dec 13;14:1326346. |