| Bioactivity | EGFR-IN-75 is an EGFRWT and EGFRT790M inhibitor with IC50 values of 0.28 μM and 5.02 μM, respectively. EGFR-IN-75 shows anticancer and antioxidant activity[1]. |
| Invitro | EGFR-IN-75 (compound 2) shows cytotoxicity against MCF-7 and A549 cell lines with IC50 values of 4.92 μM and 4.69 μM, respectively[1].EGFR-IN-75 (compound 2) also has the best antioxidant property, decreasing the radical scavenging activity by 78%[1]. |
| Name | EGFR-IN-75 |
| Formula | C10H6N6S2 |
| Molar Mass | 274.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sanaa A Ahmed, et al. Thieno[2,3- b]thiophene Derivatives as Potential EGFRWT and EGFRT790M Inhibitors with Antioxidant Activities: Microwave-Assisted Synthesis and Quantitative In Vitro and In Silico Studies. ACS Omega. 2022 Dec 3;7(49):45535-45544. |