PROTAC SOS1 degrader-3_product_DataBase

Bioactivity	PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system[1].
Invitro	PROTAC SOS1 degrader-3 (P7; 0.1-10 μM; 6 hours) induces SOS1 degradation in SW620 cells. In addition to SW620, PROTAC SOS1 degrader-3 also induces SOS1 degradation in other colorectal cancer (CRC) cell lines HCT116, C2BB, and SW1417 in a concentration-dependent manner. The half maximal degradation concentration (DC50) for SW620, HCT116, and SW1417 at 24 h is 0.59 μM, 0.75 μM, and 0.19 μM, respectively[1]. Western Blot Analysis[1] Cell Line:
Name	PROTAC SOS1 degrader-3
Formula	C34H32F3N7O6
Molar Mass	691.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yujia Bian, et al. Development of SOS1 Inhibitor-Based Degraders to Target KRAS-Mutant Colorectal Cancer. J Med Chem. 2022 Dec 22;65(24):16432-16450.

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