| Bioactivity | EGFR-IN-74 (Compound 21) is a potent EGFR inhibitor with an IC50 of 138 nM against EGFR L858R/T790M. EGFR-IN-74 induces cancer cell apoptosis[1]. |
| Invitro | EGFR-IN-74 (Compound 21) (72 h) 显示出对具有不同 EGFR 状态的细胞的抗癌活性[1]。EGFR-IN-74 (0.01 μM; 24 and 48 h) 诱导癌细胞凋亡[1]。EGFR-IN-74 与 EGFR 酶形成稳定的复合物，没有太多的结构重排[1]。 Cell Viability Assay[1] Cell Line: |
| Name | EGFR-IN-74 |
| Formula | C32H28BrF3N6O4S |
| Molar Mass | 729.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kardile RA, et al. Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening and ADME predictions. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114889. |