| Bioactivity | TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research[1]. |
| Invitro | TD1092 (0.1 μM-10 μM; 0.5-6 小时) 以剂量和时间依赖的方式有效地降解 cIAP1, cIAP2 和 XIAP [1]。TD1092 (0.01, 0.1 和 1 μM ;18 小时) 能够激活 MCF-7 细胞中的半胱天冬酶 3 和 7[1]。TD1092 (1 μM; 48 或 72 小时) 促进癌细胞死亡[1]。TD1092 (0.1 μM; 24 小时) 抑制受 TNFα 诱导的三阴性乳腺癌细胞的迁徙和入侵[1]。TD1092 (1 μM; 6 小时) 抑制 TNFα 诱导的 NF-κB 信号通路和上皮-间充质转化 (EMT)[1]。TD1092 (1 μM; 72 小时) 抑制 MCF-7 细胞生长，IG50 为 0.395 μM[1]。 Western Blot Analysis[1] Cell Line: |
| Name | TD1092 |
| Formula | C55H70N8O9 |
| Molar Mass | 987.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Park S, et al. Discovery of pan-IAP degraders via a CRBN recruiting mechanism. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114910. |