| Bioactivity | Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research[1]. |
| Invitro | Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2 MCF-7 and WI-38 cells (normal human cells) with IC50 values of 1.62, 1.46, 2.04 and 117.9 µM, respectively[1]..Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | Apoptotic agent-3 |
| CAS | 2482310-23-4 |
| Formula | C31H21N5OS |
| Molar Mass | 511.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Apoptotic agent-3
CAS: 2482310-23-4 F: C31H21N5OS W: 511.60
Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and ac
Data collection：peptidedb@qq.com
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