| Bioactivity | Droxicam (Ombolan) is a non-steroidal anti-inflammatory agent, with strong analgesic activity. Droxicam acts by inhibiting PGE2 varies, and is characterised by being a pro-drug of Piroxicam (HY-B0253). Droxicam is well tolerated with slight side effects in the said mucosa. Droxicam does not show cardiovascular or respiratory effects in cats, and inhibits peritoneal capillary permeability in mouse[1][2]. |
| In Vivo | Droxicam (0.25 和 0.5 mg/kg；口服) 在角叉菜胶诱导的大鼠水肿中表现出高抗炎活性[1]。Droxicam (ED50, p.o.; 5, 6, 7, 8 h; 7.5, 12.9, 4.8, 8.4 mg/kg) 在大鼠中对制霉菌素诱导的水肿表现出高抗炎活性[1]。Droxicam (ED50，口服，1、2、3、4 小时：0.51、0.94、1.56、4.88 mg/kg) 对紫外线光诱导红斑的豚鼠，显示出保护作用[1]。Droxicam (0.1 mg/kg, 0.33 mg/kg, 1 mg/kg; po; 每日一次) 在注射 Mycobacterium butyricum 的大鼠中显示出良好的抗关节炎活性，可抵抗原发性和继发性病变[1]。Droxicam 在防止小鼠扭体方面表现出很强的镇痛活性，对由苯基苯醌诱导、乙酰胆碱溴化物诱导的小鼠，ED50 分别为 5.3 mg/kg 和 1.1 mg/kg[1]。Droxicam (ED50=0.081 mg/kg; po) 保护大鼠免受蓖麻油引起的腹泻[1]。Droxicam 显著抑制小鼠腹膜毛细血管通透性[1]。Droxicam 在 Irwin 试验中，不会改变大鼠的行为 (80 mg/kg，i.p.) 和小鼠的行为 (160 mg/kg，p.o.)[1]。Droxicam 在大鼠中不表现出排尿酸活性，在麻醉猫中既不表现出心血管或呼吸作用，也不改变它们对乙酰胆碱、去甲肾上腺素和组胺给药的反应[1]。 |
| Name | Droxicam |
| CAS | 90101-16-9 |
| Formula | C16H11N3O5S |
| Molar Mass | 357.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Farré AJ, et al. Pharmacological properties of droxicam, a new non-steroidal anti-inflammatory agent. Methods Find Exp Clin Pharmacol. 1986 Jul;8(7):407-22. [2]. Jané F, et al. Droxicam: a pharmacological and clinical review of a new NSAID. Eur J Rheumatol Inflamm. 1991;11(4):3-9. |