| Bioactivity | JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 35 nM and 64 nM for human recombinant PDE10A and rPDE10A, respectively[1]. |
| In Vivo | JNJ-42314415 (24.7 mg/kg) 高剂量下会引起体温过低[1]. |
| Name | JNJ-42314415 |
| CAS | 1334165-90-0 |
| Formula | C19H23N5O2 |
| Molar Mass | 353.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Anton A H P Megens, et al. Pharmacology of JNJ-42314415, a centrally active phosphodiesterase 10A (PDE10A) inhibitor: a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54. |
JNJ-42314415
CAS: 1334165-90-0 F: C19H23N5O2 W: 353.42
JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 35 nM and 64 nM for human
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