Sabeluzole

CAS: 104383-17-7 F: C22H26FN3O2S W: 415.52

Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sa

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Bioactivity	Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease[1][2].
Invitro	Sabeluzole（50 nM、100 nM；细胞损伤前 20 分钟）在小脑颗粒细胞原代培养物中对谷氨酸 (50 μM) 介导的兴奋性毒性具有保护作用[1]。Sabeluzole（50 nM；7 天）抑制谷氨酸诱导的 tau 蛋白水平增加[1]。Sabeluzole（50 nM; 4 d）在人神经母细胞瘤细胞系 SH-SY5Y 中表现出神经保护作用[1]。
In Vivo	Sabeluzole（5 mg/kg，25 mg/kg；sc；两次给药，间隔 72 小时）在 20 mg/kg Chlordiazepoxide 诱导的习惯性遗忘症雄性大鼠中表现出阳性和记忆增强特性[2]。 Animal Model:
Name	Sabeluzole
CAS	104383-17-7
Formula	C22H26FN3O2S
Molar Mass	415.52
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103. [2]. Hlinák Z,et al. Sabeluzole improves social recognition and antagonizes chlordiazepoxide's effect on habituation in the rat. Psychopharmacology (Berl). 1991;104(4):505-9.