| Bioactivity | Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity. |
| Invitro | Doxorubicinol 抑制分离的乳头肌的舒张功能（即增加静息压）[1]。Doxorubicinol 在显著降低舒张功能的浓度下，阿霉素几乎完全消除钙泵活性[1]。Doxorubicinol 抑制 Ca2+ 刺激的骨骼肌肌浆网的 ATP 酶活性，并消除犬和兔心脏制备物中肌膜的 Na+/K+-ATP 酶活性[1]。Doxorubicinol 抑制 PANC-1 细胞的增殖，IC50 值为 35.4 μM，PD PaCa 细胞的 IC50 值为 44.5 μM，WD PaCa 细胞的 IC50 值为 49.5 μM[1]。 |
| Name | Doxorubicinol |
| CAS | 54193-28-1 |
| Formula | C27H31NO11 |
| Molar Mass | 545.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Olson RD, et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc Natl Acad Sci U S A. 1988 May;85(10):3585-9. |
Doxorubicinol
CAS: 54193-28-1 F: C27H31NO11 W: 545.54
Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial funct
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