Anticancer agent 110_product_DataBase

Bioactivity	Anticancer agent 110 is an anticancer agent with in vitro anticancer activity and excellent anti-leukemia potency. Anticancer agent 110 is highly cytotoxic to K-562 lineage chronic myelogenous leukemia cells at nanomolar concentrations. Anticancer agent 110 causes DNA damage and leads to apoptosis[1].
Invitro	Anticancer agent 110 (化合物 3d) (0.01 μM-100 μM) 抑制白血病 K-562 细胞，IC50 为 0.7 μM[1]。Anticancer agent 110 (70 nM、700 nM；24 h) 在 K-562 细胞中引起更高水平的 DNA 损伤[1]。Anticancer agent 110 (70 nM、700 nM；24 h) 诱导白血病细胞形态发生促凋亡变化[1]。
Name	Anticancer agent 110
CAS	887349-03-3
Formula	C18H13FN6OS
Molar Mass	380.40
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Pokhodylo N, et al. Bioisosteric replacement of 1H-1,2,3-triazole with 1H-tetrazole ring enhances anti-leukemic activity of (5-benzylthiazol-2-yl)benzamides. Eur J Med Chem. 2023 Mar 15;250:115126.

PeptideDB