IEM-1925 bromide_product_DataBase

Bioactivity	IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy[1][2].
In Vivo	IEM-1925 (10 mg/kg) 减弱了大鼠癫痫状态下的行为运动惊厥症状，将Pinel和Rovner评分中的癫痫发作强度从8分降至4分。 Animal Model:
Name	IEM-1925 bromide
CAS	258282-23-4
Formula	C17H30Br2N2
Molar Mass	422.24
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. D B Tikhonov, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74. [2]. S. I. Vataev, et al. IEM-1925, a Glutamate Receptor Channel Blocker, Increases the Latent Period and Decreases the Duration of Status Epilepticus in Rats in a Lithium-Pilocarpine Model of Epilepsy. Neuroscience and Behavioral Physiology volume 51, pages976–984 (2021).

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