| Bioactivity | Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities[1]. |
| In Vivo | Diapocynin（300 mg/kg；口服；每 12 小时一次，持续 72 小时）可显着缓解 DFP 引起的运动障碍，减轻 DFP 后前 72 小时内的癫痫样尖峰。 Diapocynin 可显着降低 DFP 诱导的反应性星形胶质细胞增生、神经变性、GP91phox、谷胱甘肽、血清亚硝酸盐或促炎细胞因子和趋化因子，如白细胞介素 (IL) IL-1α、IL-6、IL-2、IL-17A、瘦素、 IP-10[1]。 Animal Model: |
| Name | Diapocynin |
| CAS | 29799-22-2 |
| Formula | C18H18O6 |
| Molar Mass | 330.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Marson Putra, et al. Diapocynin, an NADPH oxidase inhibitor, counteracts diisopropylfluorophosphate-induced long-term neurotoxicity in the rat model. Ann N Y Acad Sci. 2020 Nov;1479(1):75-93. |