| Bioactivity | Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization[1]. |
| Invitro | Rhodblock 6 (1-30 μM) 以剂量依赖性方式强烈抑制 ROCK 活性。Rhodblock 6 还会抑制其人类直系同源物 ROCK I，并且 Rhodblock 6（100 μM；20 小时）会导致人类 HeLa 细胞中的应力纤维破裂[1]。 |
| Name | Rhodblock 6 |
| CAS | 886625-06-5 |
| Formula | C12H13N3O |
| Molar Mass | 215.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Adam B Castoreno, et al. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6(6):457-63. |