DL-Sulforaphane N-acetyl-L-cysteine

CAS: 334829-66-2 F: C11H20N2O4S3 W: 340.48

DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and metabolite of sulforaphane (HY-1375

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Bioactivity	DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and metabolite of sulforaphane (HY-13755) with longer half-life and better blood-brain barrier permeability. DL-Sulforaphane N-acetyl-L-cysteine activates autophagy-mediated downregulation of α-tubulin expression through the ERK pathway and can be used in cancer research[1][2].
Invitro	SFN-NAC (24 h) 会降低细胞活力，HA 细胞，U87MG 细胞，U373MG 细胞和 U87/TR 细胞的 IC50 值分别为 60.08 μM，35.20 μM，39.11 μM，36.20 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DL-Sulforaphane N-acetyl-L-cysteine 相关抗体: Cell Cycle Analysis[1] Cell Line:
In Vivo	SFN-NAC (10 μmol; 6 h; Oral gavage; single dose) 显着抑制小鼠结肠粘膜中的 HDAC 活性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	334829-66-2
Formula	C11H20N2O4S3
Molar Mass	340.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu HJ, et al. Sulforaphane-N-Acetyl-Cysteine Induces Autophagy Through Activation of ERK1/2 in U87MG and U373MG Cells. Cell Physiol Biochem. 2018;51(2):528-542. [2]. Dashwood R H, et al. Dietary histone deacetylase inhibitors: from cells to mice to man[C]//Seminars in cancer biology. Academic Press, 2007, 17(5): 363-369.