| Bioactivity | BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research[1][2][3]. |
| Invitro | BF389 抑制 PGE2 的产生和 LTB4 的形成，IC50s 分别为 0.84 μM 和 3.65 μM[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> BF389 相关抗体: |
| In Vivo | BF389 (1-30 mg/kg，口服，每日 5 次口服剂量) 可抑制大鼠爪肿胀，ED50 为 4.9 mg/kg，表明具有抗炎活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 127245-22-1 |
| Formula | C20H29NO3 |
| Molar Mass | 331.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bendele AM, et al. Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis. J Pharmacol Exp Ther. 1992 Jan;260(1):300-5. [2]. Wong S, et al. Antiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability. Agents Actions. 1992 Sep;37(1-2):90-8. [3]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. |