| Bioactivity | DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. DIDS inhibits anion exchange and binding to the red blood cell membrane[1][2]. |
| Invitro | DIDS (0-10 μM) 抑制 RAD51 介导的链交换[1]。DIDS (0-20 μM) 通过 RAD51 抑制 DNA 结合[1]。DIDS (10 μM; 0-60 分钟) 在 DNA 不存在的情况下刺激 RAD51 的 ATP 水解活性[1]。 |
| Name | DIDS |
| CAS | 53005-05-3 |
| Formula | C16H10N2O6S4 |
| Molar Mass | 454.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37(10):3367-76. [2]. Lepke S, et, al. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4'-diisothiocyano stilbene-2,2'-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). J Membr Biol. 1976 Oct 20;29(1-2):147-77. |