Semduramicin

CAS: 113378-31-7 F: C45H76O16 W: 873.08

Semduramicin (UK-61689) is an orally active anticoccidial agent with an IC50 value of 30.0 ng/mL for E. tenella. Semdura

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Bioactivity	Semduramicin (UK-61689) is an orally active anticoccidial agent with an IC50 value of 30.0 ng/mL for E. tenella. Semduramicin reduces the lesions of E. aceroulina, E. brunetti and E. maxima. Semduramicin (20-30 mg/kg) is well tolerates in broilers and possesses broad spectrum anticoccidial activity. Semduramicin can be used in beef and poultry industry as coccidian inhibitor and growth promoter[1][2][3].
Invitro	Semduramicin (25 mg/L；48 h) 显著减少了堆型艾美耳球虫、布氏艾美耳球虫和巨型艾美耳球虫的病变[1]。Semduramicin 显示出主要的革兰氏阳性抗菌谱[3]。Semduramicin 的抗菌谱[3]Strain
In Vivo	Semduramicin (25 mg/kg；口服，6-8 天) 显著改善了被球虫感染的十日龄肉鸡公鸡的体重增加、病变以及死亡率[1]。Semduramicin (7.5-120 mg/kg；口服，6 天) 对十天大的白来亨鸡中的柔嫩艾美耳球虫有抑制作用[3]。 Animal Model:
Name	Semduramicin
CAS	113378-31-7
Formula	C45H76O16
Molar Mass	873.08
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Logan NB, at al. Anticoccidial efficacy of semduramicin. 2. Evaluation against field isolates including comparisons with salinomycin, maduramicin, and monensin in battery tests. Poult Sci. 1993 Nov;72(11):2058-63. [2]. Cao V, et al. Treatment of Lasalocid A, Salinomycin and Semduramicin as ionophore antibiotics in pharmaceutical wastewater by PAMAM-coated membranes[J]. Environmental Technology & Innovation, 2020, 20: 101103. [3]. Ricketts A P, et al. Anticoccidial efficacy of semduramicin in battery studies with laboratory isolates of coccidia[J]. Poultry science, 1992, 71(1): 98-103.