| Bioactivity | DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential for malaria treatment[1]. |
| Target | IC50: 261 nM (HsDHODH) |
| Invitro | DHODH-IN-3 (compound 3) show good inhibitory effects on HsDHODH with IC50 value of 261 nM. It binds to HsDHODH with a Kiapp value of 32 nM[1]. |
| Name | DHODH-IN-3 |
| CAS | 1148126-04-8 |
| Formula | C17H13ClN2O2 |
| Molar Mass | 312.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.J Med Chem. 2009 May 14;52(9):2683-93. |
DHODH-IN-3
CAS: 1148126-04-8 F: C17H13ClN2O2 W: 312.75
DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC50 value of261
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