| Bioactivity | SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii[1]. |
| In Vivo | SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 µg/ml, 0.0113 µg/ml per mg/ml, 1.0 h and 0.224 µg.h/ml, respectively[1].SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with P. yoelii. SJ000025081 can result in a 90% suppression of the parasitemia[1]. Animal Model: |
| Name | SJ000025081 |
| CAS | 421571-66-6 |
| Formula | C28H30FNO5 |
| Molar Mass | 479.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. W Armand Guiguemde, et al. Chemical genetics of Plasmodium falciparum. Nature.. 2010 May 20;465(7296):311-5 |
SJ000025081
CAS: 421571-66-6 F: C28H30FNO5 W: 479.54
SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression
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