| Bioactivity | Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM[1]. |
| Target | IC50: 120 nM (Ras-Raf protein interaction). |
| Name | Cyclorasin 9A5 |
| CAS | 1782098-79-6 |
| Sequence | Cyclo({d-Ala}-Arg-Arg-Arg-Ala-Arg-Phe-{Nal}-Gln-Trp-Thr) |
| Shortening | Cyclo({d-Ala}-RRRARF-{Nal}-QWT) |
| Formula | C75H108FN25O13 |
| Molar Mass | 1586.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Koh Takeuchi, et al. Conformational Plasticity of Cyclic Ras-Inhibitor Peptides Defines Cell Permeabilization Activity. Angew Chem Int Ed Engl. 2021 Mar 15;60(12):6567-6572. |
Cyclorasin 9A5
CAS: 1782098-79-6 F: C75H108FN25O13 W: 1586.82
Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interact
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