CYP1B1-IN-4

CAS: 2685779-55-7 F: C18H14N2O2S W: 322.38

CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cy

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].
Invitro	CYP1B1-IN-4 (化合物15) (100 μM; 37 ℃; 0-60 min) 在人和大鼠肝微粒体中均具有体外稳定性，而在小鼠肝微粒体中稳定性较低[1]。CYP1B1-IN-4 (1 nM-10 μM) 抑制 CYP1A1, IC50 为 3.82 μM[1]。Cyp1b1-IN-4 (100 μM; 72 h) 对 HEK293 细胞无细胞毒性[1]。
Name	CYP1B1-IN-4
CAS	2685779-55-7
Formula	C18H14N2O2S
Molar Mass	322.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hachey AC, et al. Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach. J Med Chem. 2022 Dec 15.

HIV-1 inhibitor-50