| Bioactivity | DENV-IN-10 is a potent tetravalent dengue inhibitor, with EC50s of 1.36, 0.87, 0.94, and 0.95 μM against DENV-1-4 serotypes, respectively. DENV-IN-10 is a post-entry replication inhibitor that appears to be specific for cells of primate origin[1]. |
| Invitro | DENV-IN-10 (10 μM; 在 DENV 感染之前、感染期间或感染后 2, 6, 12, 24 h 添加) 在感染前和感染后没有显着的抗病毒活性，在感染后 2 小时添加降低感染性病毒颗粒的水平，即使在感染后 24 小时添加也仍然有效[1]。DENV-IN-10 (10 μM; 24-60 h) 降低感染 DENV-2 的 Huh-7 细胞中的病毒 RNA 拷贝数和病毒蛋白 NS3 和 NS5 的表达[1]。DENV-IN-10 (0.1-20 μM) 显着抑制 DENV-2 在灵长类动物细胞系中的复制，但在蚊子细胞和幼仓鼠肾细胞中的 EC50 较高[1]。 |
| Name | DENV-IN-10 |
| Formula | C26H25N3O4S |
| Molar Mass | 475.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Felicetti T, et, al. Functionalized sulfonyl anthranilic acid derivatives inhibit replication of all the four dengue serotypes. Eur J Med Chem. 2023 Apr 5;252:115283. |