CP 376395 hydrochloride_product_DataBase

Bioactivity	CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2].
Invitro	CP 376395 完全拮抗大鼠大脑皮层和人 CRF1 受体中 oCRF 刺激的腺苷酸环化酶活性，表观 Ki 值为 12 nM，表明具有拮抗剂功能活性。对人类CRF1受体亚型具有高度选择性；对 CRF2 受体的亲和力 >10000 nM。它对 40 种神经递质受体和离子通道的亲和力大于 1 µM[1]。 0 --> CP 376395 hydrochloride 相关抗体:
In Vivo	CP 376395（10-20 mg/kg，腹腔注射，雄性B6小鼠）会减少 H2O 和食物摄入量，增加蔗糖摄入量，减少 EtOH 摄入量，但不会减少 EtOH 偏好[2]。 Animal Model:
Name	CP 376395 hydrochloride
CAS	1013933-37-3
Formula	C21H31ClN2O
Molar Mass	362.94
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92. [2]. Giardino WJ, et al. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol Clin Exp Res. 2013 Jul;37(7):1161-70.

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