| Bioactivity | COX-2/sEH-IN-2 (Compound 8o) is a dual COX-2/sEH inhibitor with cardioprotective effects, exhibiting IC50 values of 10.50 μM and 2.20 nM respectively, and COX-2/sEH-IN-2 can also inhibit the activity of 5-LOX (IC50=3.05 μM). COX-2/sEH-IN-2 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects[1]. |
| Target | IC50: 10.5 μM (COX-2).IC50: 2.20 nM (sEH).IC50: 3.05 μM (5-LOX). |
| Formula | C18H15N7O |
| Molar Mass | 345.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Al-Wahaibi L H, et al. New Diaryl-1, 2, 4-triazolo [3, 4-a] pyrimidine Hybrids as Selective COX-2/sEH Dual Inhibitors with Potent Analgesic/Anti-inflammatory and Cardioprotective Properties[J]. ACS Omega, 2024. |