| Bioactivity | (R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. (R)-HTS-3 suppresses the C20:4content of PE, PC, and PS, while promoting a correspondingelevation in C22:4 phospholipids and a paradoxical increase inC20:4 phosphatidylinositol (PI) lipids[1]. |
| Invitro | (R)-HTS-3 (10 µM) 可缓解RSL3 诱导的 HT-1080 和 786-O 癌细胞铁死亡。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (R)-HTS-3 相关抗体: |
| CAS | 2771208-83-2 |
| Formula | C17H18F2N2O |
| Molar Mass | 304.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alex Reed, et al. LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis. ACS Chem Biol. 2022 Jun 17;17(6):1607-1618. |
(R)-HTS-3
CAS: 2771208-83-2 F: C17H18F2N2O W: 304.33
(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. (R)-HTS-3 suppre
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