| Bioactivity | CIL62 is a caspase-3/7-independent cell death inducer. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death[1]. | ||||||||||||
| Invitro | 19 µM (5 µg/mL) Necrostatin-1 suppresses CIL62, but CIL62 is not suppressed by the ferroptosis inducers (antioxidants or iron-chelators)[1]. | ||||||||||||
| Name | CIL62 | ||||||||||||
| CAS | 117593-36-9 | ||||||||||||
| Formula | C23H26O5 | ||||||||||||
| Molar Mass | 382.45 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kenichi Shimada, et al. Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of Ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503. |