| Bioactivity | MODAG-001 can bind to synuclein fibrils in a rat brain. MODAG-001 is a candidate α-syn imaging probe[1][2][3]. | ||||||||||||
| Invitro | MODAG-001 shows strong binding affinity to recombinant human α-syn aggregates, but fail to bind real α-syn aggregates in human brain sections[2]. | ||||||||||||
| Name | MODAG-001 | ||||||||||||
| CAS | 2648041-72-7 | ||||||||||||
| Formula | C16H15BrN4 | ||||||||||||
| Molar Mass | 343.22 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Bousiges O, et al. Biomarkers of Dementia with Lewy Bodies: Differential Diagnostic with Alzheimer's Disease. Int J Mol Sci. 2022 Jun 7;23(12):6371. [2]. Bian J, et al. Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands. Eur J Med Chem. 2021 Dec 15;226:113887. [3]. Akasaka T, et al. Synthesis and evaluation of novel radioiodinated phenylbenzofuranone derivatives as α-synuclein imaging probes. Bioorg Med Chem Lett. 2022 May 15;64:128679. |