| Bioactivity | CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1]. | ||||||||||||
| Invitro | CFTR corrector 8 (compound 12) shows EC50s of 1 μM (CSE-HRP assay) and 3 μM (HBE-TECC assay) [1].CFTR corrector 8 exhibits hepatocyte clearance rate of 1250/775 L/hr/kg (human/rat)[1]. | ||||||||||||
| Name | CFTR corrector 8 | ||||||||||||
| CAS | 1918142-35-4 | ||||||||||||
| Formula | C29H27F2NO7 | ||||||||||||
| Molar Mass | 539.52 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449. |