| Bioactivity | RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders[1]. |
| Invitro | RORγt inverse agonist 30 (compound 1) inhibits mouse Th17 cell differentiation with an IC50 of 0.67 μM[1]. |
| In Vivo | RORγt inverse agonist 30 exhibits favorable pharmacokinetics profiles with T1/2 of 2.3 min, CLint of 612 μL/min/mg and CLint(liver) of 2423.5 mL/min/kg[1]. |
| Name | RORγt inverse agonist 30 |
| CAS | 1445901-41-6 |
| Formula | C24H31N3O3S |
| Molar Mass | 441.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nannan Sun, et al. Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases. Eur J Med Chem. 2020 Feb 1;187:111984. |
RORγt inverse agonist 30
CAS: 1445901-41-6 F: C24H31N3O3S W: 441.59
RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear
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