| Bioactivity | ZQ-16 is a potent and selective GPR84 agonist with an EC50 value of 0.213 μM. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120[1]. |
| Invitro | ZQ-16 以剂量依赖的方式诱导钙反应，EC50 值为 0.213 μM[1]。ZQ-16 还在表达 GPR84 的 HEK293 细胞中诱导毛喉素刺激的 cAMP 积累的剂量依赖性减少，EC50 值为 0.134 μM[1]。 ZQ-16（10 μM；5 分钟）还在表达 GPR84 的 HEK293 细胞中诱导 ERK1/2 的磷酸化[1]。ZQ-16 诱导 GPR84 脱敏、内化和 β-arrestin2 募集。ZQ-16 在表达两种蛋白的 HEK293 细胞中诱导 β-Arrestin2 向 GPR84 的剂量依赖性募集，EC50 值为 0.597 μM[1]。 Western Blot Analysis[1] Cell Line: |
| Name | ZQ-16 |
| CAS | 376616-73-8 |
| Formula | C10H16N2O2S |
| Molar Mass | 228.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qing Zhang, et al. Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84. J Pharmacol Exp Ther. 2016 May;357(2):337-44. |
ZQ-16
CAS: 376616-73-8 F: C10H16N2O2S W: 228.31
ZQ-16 is a potent and selective GPR84 agonist with an EC50 value of 0.213 μM. ZQ-16 has no activity on the other free f
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