| Bioactivity | D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8+ cells and shows anti-tumor activity[1]. |
| Target | C50: 0.17 nM (CD73) |
| In Vivo | CD73-IN-14 (10, 25, 50 mg/kg; p.o.; twice-a-day for 20 days) shows anti-tumor activity in mouse[1].br/>Pharmacokinetic Parameters of CD73-IN-14 in rats[1]. PO Dose (mg/kg) |
| Name | CD73-IN-14 |
| CAS | 2407356-67-4 |
| Formula | C26H26ClN7O9 |
| Molar Mass | 615.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li J, et al. Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates In Vivo Antitumor Activity. J Med Chem. 2022 Dec 18. |
CD73-IN-14
CAS: 2407356-67-4 F: C26H26ClN7O9 W: 615.98
D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases th
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