Nampt-IN-10 trihydrochloride_product_DataBase

Bioactivity	Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC50 values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC)[1].
Target	IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)
Invitro	Nampt-IN-10 trihydrochloride (0-1 μM; 72 h) 对 A2780, CORL23, c-Kit 和 HER2 的表达细胞株具有细胞毒性。 Cell Cytotoxicity Assay[1] Cell Line:
Name	Nampt-IN-10 trihydrochloride
Formula	C27H31Cl3FN5O2
Molar Mass	582.92
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

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