| Bioactivity | CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways[1]. |
| Invitro | CYP1B1-IN-3 (compound 77) (3.75-30.0 μM; 72 h) 增加 A549/Taxol 细胞对Taxol (0.06-1 μM) 的敏感性[1]。CYP1B1-IN-3 (2.5, 5, 10 µM) 抑制 A549 细胞和 A549/Taxol 细胞的迁移和侵袭[1]。CYP1B1-IN-3 (2.5, 5, 10 µM; 24 h) 抑制 A549/Taxol 细胞中的 AKT/ERK、FAK/SRC 和 EMT 通路[1]。 Western Blot Analysis[1] Cell Line: |
| Name | CYP1B1-IN-3 |
| Formula | C20H16FN3O2S2 |
| Molar Mass | 413.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mao J, et al. Structure-Based Drug Design and Synthesis of Novel N-Aryl-2,4-bithiazole-2-amine CYP1B1-Selective Inhibitors in Overcoming Taxol Resistance in A549 Cells. J Med Chem. 2022 Dec 22;65(24):16451-16480. |