Bcl-2-IN-11_product_DataBase

CAS: 2760536-88-5 F: C45H49ClFN7O8S W: 902.43

Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows w

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Bcl-2-IN-11 (compound 6) is a potent and selective Bcl-2 activity inhibitor, with an IC50 of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC50 > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia[1].
Invitro	Bcl-2-IN-11 (compound 6) 可抑制 RS4;11 急性淋巴细胞增殖，IC50 为 2.37 nM[1]。
Name	Bcl-2-IN-11
CAS	2760536-88-5
Formula	C45H49ClFN7O8S
Molar Mass	902.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kong Xianglong, et al. Heterocyclic compound as bcl-2 inhibitor. WO2022028353A1.

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