| Bioactivity | BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer[1]. | ||||||||||||
| Target | IC50: 4 nM (MKK4); 181 nM (MKK7) | ||||||||||||
| Invitro | BSJ-04-122 对 MKK4 和 MKK7 具有抑制活性，IC50 值分别为 4 nM 和 181 nM[1]。BSJ-04-122（1、5、10 μM；6 h）诱导 JNK 磷酸化的强烈减少[1]。BSJ-04-122（0、1.25、2.5、5、10、20 μM；72 h）与 JNK-IN-8 结合使用时显示出增强的抗增殖作用[1]。 Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | BSJ-04-122 | ||||||||||||
| CAS | 2513289-74-0 | ||||||||||||
| Formula | C15H12ClN5O | ||||||||||||
| Molar Mass | 313.74 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Jie Jiang, et al. Discovery of Covalent MKK4/7 Dual Inhibitor. Cell Chem Biol |
BSJ-04-122
CAS: 2513289-74-0 F: C15H12ClN5O W: 313.74
BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, r
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