Antibacterial agent 130_product_DataBase

Bioactivity	Antibacterial agent 130 is a 1,1-diarylthiogalactoside, used for targeting the Pseudomonas aeruginosa LecA. Antibacterial agent 130 shows high affinity toward LecA (Kd=1 μM). Antibacterial agent 130 has antibiofilm activity, but lacks bactericidal activity. LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion and biofilm formation[1].
Invitro	Antibacterial agent 130 (化合物 8a) (0.08-5 mM; 2-24 h) 剂量依赖性抑制细菌生物膜的形成，在 5 mM 剂量下的抑制率是 100%[1]。Antibacterial agent 130 (0.01-5 mM; 24 h) 浓度高于1.25 mM 时对 MRC-5 细胞系 (人胎儿肺成纤维细胞) 有细胞毒性[1]。
Name	Antibacterial agent 130
CAS	1502721-60-9
Formula	C23H28O10S
Molar Mass	496.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bruneau A, et al. Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties. Eur J Med Chem. 2022 Dec 15;247:115025.

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